Cellular prion protein (PrPc) is a high affinity receptor for soluble oligomeric AB42 (see Figure 2, Strittmater et al., 2010), mediating toxic effects on synaptic plasticity. PrPc represents a target in Alzheimer?s disease (AD) directly disrupting the signaling pathway of soluble A?42. Please address the following questions. 1) Describe an […]