Q1. Drug effects are conditional. Drugs can target redundant gene products not limited to model systems Active compounds can help define drug leads and new “druggable” targets. Target identification can be technically challenging probably not as random as mutagenesis. What is essential for effective chemical genetics? Q2. Describe the term […]

You are free to introduce other concepts/frameworks as well.  For the future, be sure to indicate both actual and potential competitors and collaborators.  Your paper should be ten pages, double-spaced, using 12-point type, not including appendixes, exhibits, and/or references.  As with your individual papers, you may either write an essay […]

You have four colonies of mice that are independent of each other. Each has a true-breeding mutation resulting in a short tail. For each colony, the short tail phenotype is recessive to the wild-type long-tail phenotype. You do not know whether these four short tail phenotypes are due to mutations […]

Enalaprilat is a competitive inhibitor of the angiotensin-converting enzyme (ACE), which cleaves the blood-pressure regulating peptide angiotensin  I. ACE has a KM = 52 ?M for angiotensin  I, which is present in plasma at a concentration of 75 ?M. When enalaprilat is present at 2.4 nM, the activity of ACE […]