Q1. Mr. and Mrs. Lehman have sought genetic counselling. Mrs. Lehman is concerned since she is unexpectantly pregnant and her husband’s brother died of Tay-Sachs disease. She can recall no incidence of Tay-Sachs disease in her own family. Do you think biochemical testing must be recommended to detect the deleterious gene in Mrs. Lehman?

Q2. Martha decides to double her tidal volume and decrease her respiratory frequency to half, whereas George decides to halve his tidal volume and to double his respiratory frequency. Which one increased their alveolar ventilation, or do they stay the same? Why with appropriate reason?