Which marker appears to be closest to the trait allele
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April 7, 2020Solution-Autism spectrum disorders
April 7, 2020Which marker appears to be closest to the trait allele
The table below gives the Z scores for four different marker loci (A, B, C and D) with respect to possible linkage to a monogenic, fully penetrant trait.
|
E |
0 |
0.05 |
0.1 |
0.15 |
0.2 |
|
Z(A) |
-3.0 |
-2.0 |
-1 |
0 |
0.3 |
|
Z(B) |
0.1 |
0.2 |
1.0 |
0.6 |
0.3 |
|
Z(C) |
4.0 |
3.0 |
2.0 |
0.8 |
0.2 |
|
Z(D) |
? |
2.0 |
4.0 |
4.2 |
2.5 |
a. Which markers is/are significantly linked to the trait allele anywhere within 0?È?0.2?
b. Which marker appears to be closest (fewest cM away) to the trait allele?
c. Which markers, if any, definitely is/are NOT linked to the trait allele specifically at È=0?
(they may be linked at other values of È)
d. For which markers, if any, can we make no definite conclusion about linkage?
