Use the Goldman equation and the Goldman equation simulator to answer the following questions. When answering %u201CWhy%u201D questions, do so in one-two sentences.

Start with the default conditions in the simulator.

PK = 100 Ko = 10 mM Ki = 100

PNa = 1 Nao = 100 Nai = 1

PCl = 10 Clo= 100 Cli = 10

a) What is the voltage of a cell that has these values? Why

b) If the relative potassium permeability was changed to 1, what would be the voltage of the cell? Why?

c) Change the permeability of K back to 100. If the permeability to chloride is changed from 10 to 100, will there be a voltage change? Why?

d) Change the permeability of chloride back to 10. Now, change the extracellular concentration of potassium to 90 mM. What is the voltage of the cell? Why?

e) Now change the extracellular concentration of potassium to 200. What is the voltage of the cell? Why?

f) Now change the permeability to potassium to 9999. Is there a further large change in the voltage of the cell? Why?