Explain (include a diagram if you wish) how the activity of protein kinase A (PKA) is regulated by binding of cAMP. Include in your explanation:
•How the term “consensus sequence” (-RRX(S/T)Y-) relates to the activity of PKA where X is a small amino acid residue (e.g., G), and Y is a large hydrophobic residue (e.g., I), making it clear that you know how the term relates to the function and activation of PKA; •the term “pseudosubstrate sequence”;
•where in the structure of PKA cAMP binds;
•what happens to the structure of PKA when cAMP binds and how that relates to PKA activity.