In order to ensure that chromosomal DNA is replicated once and only once in each cell cycle, eukaryotic cells have evolved a complex system of control involving Cdc6, a pre-replicative complex, Origin recognition complex and S-Cdk.

A. You activate the promoter of Cdc6 so that gene expression and protein production also occurs in mid-S phase. What do you predict will happen during the cell cycle?

B. What if Cdc6 always behaved as if it were phosphorylated?