The ability of the gamma herpes virus to establish latency in the lymphocyte behavior is a crucial determinant in chronic gamma herpes virus. The nuclear factor NF-kB family is the main target of the gamma herpes virus as it forms an ample environment for the host cell survival, transformation and proliferation. The primary role of the NF-kB signaling has not been known regard establishment of latency. The latent infection established on the white blood cells impeded the ability of the body to defend itself from the chronic gamma herpes virus, allowing its prolonged life in the body. The malfunctioning of the lymphocytes and the consequent inability of the body to fight the virus allows it to replicate and transform massively in the hosts body. The author’s main point is that NF-kB is a very crucial agent that aides in the establishment of the chronic gamma herpes virus. This review shall critique the article by Krug et al. and offer significant insights into the ideas developed in the article.

The purpose as to why the author created this article is to add to the existing knowledge and offer insights into the reason as to why the chronic gamma herpes virus persists. This has been possible through highlighting the major factors that favor its growth, among them the NF-kB factor among others. The intended audiences are scholars. The knowledge developed is used to offer significant insights into the topic and enlighten the scholars on the issues that have been so far addressed and what remains unaddressed. The author makes use of scientific evidence to support the information in the article. Additionally, the authors have used an experimental design into the investigation and developed the experiment in manner that allowed them to draw inferences as per the objectives of the study. The approach involved engineering a transgenic virus that produced a repressor of the NF-kP activation. The findings of this move were that the virus was not efficient and could not come up with latency in B cells in the lungs and spleen. From this experiment, it was apparent that there was no way to free the B-cell infection through forced expression of the Bcl-“c protein.

There are no biases in the experiment. This is because the experiment is scientific and involves controls. For most of the scientific experiments, it is hard to establish a bias especially where applied science such as biology is involved. However, the author has not included any assumptions made. This is so because the experiments are conducted in an environment where the population is at its natural environment and only the introduction of the engineered virus could account for any changes in results. The argument presented is logical as it is based on a scientific experiment, and the results cannot be manipulated. The reasoning, on the other hand, is also logical because the results drawn in the experiment are completely based on existing theory and experimentation.

The text is well organized and easy to read. This is because the author begins with an abstract that gives the reader the entirety of the issue ha aims to address. The author’s summary also comes before the body and after the introduction to enable a reader to get a rough idea of the scope and the result. Graphical representations and pictorials are also used to reinforce the writings. This enables the reader to interact with the material and understand the core source of the literature. The author also presents the findings in a logical and cohere not manner allowing a scholar to comprehend the text.

The facts presented by the author are also accurate as they are based on an experiment. The representations in the pictorials are also accurately represented in the wording. Terms have also been clearly defined allowing the reader to understand the ideas presented. The author has also tried to use simple biological phrases and terms in some of the instances to enable the reader easily to comprehend the intended message in a subject that can be quite technical in writing. Sufficient points have been explored to provide evidence allowing the author to also refer to previous studies to ensure that the findings are coherent with previous studies.

The arguments presented support the main point. Despite varied opinions on the issues arising, the authors have managed to prove their point through the experiment. The text also meets the requirements of the intended audience enabling scholars to comprehend the topic more effectively and form opinions on the same. The text has also represented the views of others among them Souza, Kim, Siebenlist and Matta among others, enabling the authors to develop a good experimental design.

The manner in which the text is presented enables ma to properly read with ease. The presence of many subtopics allows one to take breaks, read the topic that interests him/her most and allows one to skip a section to be read later. The article also broadens one’s mind by forming a basis into genetic studies. This enables a scholar to do well and understand other similar research studies better.