Solution-Use an alternative pathway for glucose catabolism

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April 7, 2020
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April 7, 2020

Solution-Use an alternative pathway for glucose catabolism

Some anaerobic bacteria use an alternative pathway for glucose catabolism, as shown in the attached figure, that converts glucose to acetate rather than pyruvate. The first part of the pathway (glucose to fructose bis-phosphate) is identical to glycolysis. In the second part of the alternative pathway, Enzymes 1-6 all have mechanisms/activities analogous to enzymes in glycolysis. Note that there are two C-C bond cleavage reactions in the new pathway (A to B+C and C to B+D). All the steps where ATP is consumed or made are shown. However, the addition or loss of NAD+/NADH, Pi, H2O, or H+ have not been shown explicitly. Draw the structures for the intermediates B, F, G, H, and I. Include the other reaction participants as needed.

Attachment:- Acetate-metabolism-quiz.pdf