Question 1: Probenecid inhibits the active resorption (recovery) of uric acid in the kidney. This causes urinary excretion of excess uric acid that is normally found in the bloodstream.

Part 1: Does the drug Probenecid raise or lower the level of uric acid in the body?

Part 2: If uric acid levels are elevated in a patient’s bloodstream it could lower the pH of the patient’s blood. The body maintains blood pH by depositing uric acid. Where can the body deposit uric acid?

Part 3: Why is deposition of uric acid (as related to your answer from Part 2) harmful to the body?

Part 4: Probenecid may be useful in treating a disease, what disease do you think probenecid would treat? DEFEND your answer. Provide the disease and the signs/symptoms and clearly state how the drug would treat the signs/symptoms.