1- List the intended use, mechanism of action (how does the drug work), type of controlled release and/or targeting used, and the company that produces each of the following formulations:

Ambien-CRDepakote-EREffexor-XRSinemet-CRPaxil-CR

2- A “health guru” has stated that “the makeup you put on your skin goes into your bloodstream”. Using what you know about the relationship between molecular weight and lipophilicity and skin permeation, discuss the conditions under which this statement may be correct.

3- A drug may be either extracted from a plant or produced synthetically in the laboratory. Which method is likely to result in a compound that may be toxic to the body?