Solution-Calculate the frequency of the lm and ln alleles

The MN blood group in humans is under the control of a pair of codominant alleles, LM and LN. In a group of 556 individuals, the following genotypic frequencies are found:

167 MM
280 MN
109 NN

(a) Calculate the frequency of the LM and LN alleles.

(b) Test (using the Chi-squared test) whether the genotype frequencies conform to the Hardy-Weinberg distribution.

Genotypes
MM MN NN Sum
Observed number
Observed frequency
Expect frequency
Expected number
(O-E)2/E

Solution

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