Solution-An introduction to genetic processes

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Solution-An introduction to genetic processes

Lab: An Introduction to Genetic Processes

Part A: DNA Replication and Protein Synthesis and Sources of Variability Exercise

Exercise 1. Illustrate your understanding of complimentary bases and DNA Replication by providing the triplet of bases that are complimentary to the original DNA triplet, and that would attach to the exposed DNA triplet during the first state of DNA replication.

Sample DNA Triplet

DNA triplet replicated with complimentary Bases

1. AAG

example: TTC

2. TCT

 

3. GCC

 

4. ATA

 

5. TGA

 

6. CCA

 

7. GTT

 

8. GCA

 

9. AAA

 

10. GGT

 

Exercise 2: Illustrate the rule of complimentary bases and the process of Protein Synthesis, using the following partial DNA sequence that codes for the production of collagen. Complete the following table, using Table 3.1 as a reference.

DNA

Transcribewith mRNA 

Translatewith tRNAAmino Acid(see Table 3.1)

 

 

1. ATG

 

 

 

 

2. CCC

 

 

 

 

3. GGC

 

 

 

 

4. CTT

 

 

 

 

5. ATT

 

 

 

 

6. TTC

 

 

 

 

7. TAC

 

 

 

 

8. AAC

 

 

 

 

9. TTT

 

 

 

 

10. GGT

example: CCA 

Proline 

 

 

2395_Amino acid.png

Exercise 3: Illustrate the role of mutation in Protein Synthesis

Step One: Transcribe the DNA strand for normal hemoglobin with mRNA complementary bases:

C A C G T G GA G T G A G G A C T C C T C T TT A G A C G G C A C T G A C G G A A T A C CCCC

Step Two: Using the chart attached as a reference “translate” each triplet of bases above with the corresponding  amino acid:

(see APPENDIX Table 3-1)

Step Three:  In the original DNA strand, a point mutation HAS occurred and the third thymine (counting left to right in the original DNA code) has been replaced by adenine. Retranslate that particular amino acid where that point mutation has occurred:

Step Four: This point mutation causes a very specific illness described in your text. What is this illness and what are the consequences for an individual with this point mutation?

Part B: Analyzing Karotypes and Cellular Genetics

Exercise 1: Review the following karyotype and answer the related questions below:

1981_Amino acid.png

FIGURE 1.9 Karyotype for Question 3.

Courtesy: National Human Genomr Research Institute

A. Which chromosomes are autosomes and which are sex chromosomes?

B. Is this a male or female?

C. This is an abnormal genetic sequence. What is abnormal about it?

D. What is the name of this abnormality and what are the consequences of this abnormality for Being a human being?

Exercise 2: Review the following karyotype and answer the related questions

813_Amino acid.png

A. Is this a male or female?

B. This is an abnormal genetic sequence. What is abnormal about it?

C. Provide an account or lived experience of this abnormality for an individual human being. (cite your source)

Exercise 3: Review the following Karotype and answer the related questions below:

1011_Amino acid.png

FIGURE 1.9 Karyotype for Question 3.

Courtesy: National Human Genomr Research Institute

A. Is this a male or female?

B. This is an abnormal genetic sequence. What is abnormal about it?

C. Provide an account or lived experience of this abnormality for an individual human being. (cite your source)

790_Amino acid.png

1. In Figure 1.16. blood samples are taken from a gate (t), an injured woman (S1). and her former husband (S2). The woman claimed that she attacked by hes former husband. The man had a cut on his hund, which he explained as a cut fron a broken water glass. is the unknown sampIe from her wound. from her former husband. or froni an unknown third person?

 

1349_Amino acid.png

2. From the same case, a second blood ampIe was collecied fron a stain on the floor of the former husband’s home (Figure 1.17). Is this stain from the woman. her former husband, or an unknown third person?

 

1586_Amino acid.png

3. A third blood sample was collected from a knife in the alley two blocks from the woman’s home (Figure 1.18). Is this stain fron the woman, her former husband or an unknown third person?