Question: A couple’s only child has Down Syndrome. An examination of the child’s karyotype reveals that he has 46 chromosomes per cell, but that one chromosome is unusually large, and appears include large portions of chromosome 14 and chromosome 21. The couple fears that if they have another child, it will also have Down Syndrome. a. Estimate the probability that their next child would have Down Syndrome. Show your work. b. The mother is 25, and learned from her genetics course that for a woman her age, the chance of giving birth to a child with Down syndrome is 1 in 1205. Should the couple expect that their chances of having a Down syndrome child are about 1 in 1205? Explain. (Note for b: you can assume that the observation of 1 in 1205 women having a Down- Syndrome child is accurate. In other words, there was no significant sampling error.)