While studying the Michaelis – Menton kinetics of enzymes in the TCA cycle, the synthetic hydrocarbon malonate was shown to act as a competitive inhibitor of one of the enzymes. At first, the identity of the inhibited enzyme was unknown but further tests revealed that this inhibited TCA enzyme was unusual because it was bound to the inner mitochondrial membrane, unlike any of the other TCA enzymes.

Predict which of the TCA enzymes was inhibited by malonate; explain how you know. List details of the reactions catalyzed by the membrane bound TCA enzyme you named in the first part. Be sure to include both the TCA reaction and any redox reactions that are catalyzed by the enzyme.