A plasma membrane with surface area of 5000 µm2; there are 106 phospholipid molecules per µm2 in each leaflet of the membrane; there are 3000 molecules of flippase enzyme associated with the plasma membrane; each flippase enzyme molecule can catalyze 100 flips per second (we’ll ignore enzyme specificity for the moment).

What is the maximum rate of inappropriate spontaneous phospholipid flips, in flips/sec for the whole plasma membrane, that can be reversed by the action of the flippases?