In the signal transduction lecture , we established that the BCR-ABL translocation creates a membrane bound receptor with constitutive kinase activity. What defect is associated with this oncogenic mutation?

A. An increase in phosphorylation of the substrate (compared to wild type)
B. A defect that attenuates signaling from the BCR-ABL kinase
C. A failure of the BCR-ABL fusion gene to localize to the plasma membrane
D. A decrease in phosphorylation of th esubstrate (compared to the wild type)
E. Apoptosis