How lac operon and trp operon function control transcription

Question: Suppose a DNA mutation changes the consensus sequence at the -35 location so that sigma factor does not bind there as well. Explain how a mutation could inhibit the binding of sigma factor to DNA. Describe two specific base substitutions you think would inhibit the binding of sigma factor. Explain why you think your base substitutions would have this effect.

Question: Compare and contrast how the lac operon and the trp operon function to control transcription

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