Plasma proteins do not ordinarily enter the glomerular filtrate. In the presence of pathology that makes the glomerulus leaky, plasma proteins can be filtered with serious consequences for renal function, and also for other functions of the body.

Consider an individual who develops a pathology that results in a leaky glomerulus.

1. Predict the changes (increase/decrease/no change) that will be present in the following parameters as a consequence of this pathology.
A. plasma protein concentration
B. plasma colloid osmotic pressure
C. plasma volume
D. interstitial fluid volume

2. As a result of fluid shifts between the vascular and the interstitial compartments additional changes in function affect cardiovascular and renal function. Predict the changes (increase/decrease/no change) that will occur in the following parameters.
A. blood pressure
B. GFR
C. plasma renin concentration
D. plasma aldosterone concentration
E. Vasopressin secretion