Please provide a reasonably detailed explanation and weblinks/book names of your resources at the bottom of your answer. However, please be concise to the question — no dissertation-sized answer please! Thank you!

For many of the mammalian Hox genes, it has been possible to determine that some of them are more similar to one of the insect HOM-C genes than to the others. Describe an experimental approach using the tools of molecular biology that would allow such a determination.