Evolution of vaccine development against pneumococcal pneumonia.

Topic: Evolution of vaccine development against pneumococcal pneumonia.
-The word limit is 4000-6000 words.
-Provide me or send to me all references that you will use in my paper because I need the abstract for each reference you will use.
-Table of content is needed.
These are the organization and outlines for the assignment:
– Abstract.
€¢ Introduction to the topic:
€¢ Background information about pneumococcal pneumonia infection:
€¢ The causative agent
€¢ Disease syndromes caused by it.
€¢ Characteristics of the diseases.
€¢ Manifestations of the disease.
€¢ Diagnosis and the current therapeutic strategies of the disease.
€¢ Epidemiology including the spread, worldwide incidence, prevalence, pandemic, significance to the public health and the economic cost.
€¢ Source and reservoir+ incubation period.
€¢ Modes of the transmission of the pathogen.
€¢ Mechanisms of pathogenesis:
€¢ Virulence factors and those that need attention in vaccine development.
€¢ Risk factors.
€¢ People at risk.
€¢ Evolution of vaccine development against pneumococcal infection:
€¢ Immunization and prophylaxis against pneumonia.
€¢ Serotype diversity.
€¢ The specificity of immune response against serotypes.
€¢ Types of vaccines undergoing trials.
€¢ Immunization schedule.
€¢ Current vaccines undergoing trials.
€¢ Their benefits and limitations.
€¢ The novel alternatives for third generation pneumococcal vaccines.
€¢ Burden and cost effectiveness of vaccination.
€¢ Current status of the development of improved vaccines and the ways by which the improved vaccines will be better than the currently used vaccines.
€¢ Discussion:- Indicate all of previous different evolutions.
€¢ Conclusion + future directions for vaccine development.