Describing the mitochondrial atp synthase

Mitochondrial ATP synthase comprises of several proteins, and some of these proteins are encoded by the genes in nucleus. One of these proteins is called S. A mutation in S gene deletes 21 base pairs which are immediately 3′ to the start codon. The mutant S gene is transcribed and translated however the S protein remains in cytoplasm. This mutant yeast cell may only grow anearobically, however the wild type yeast can grow anaerobically or aerobically. Yeast grows as a haploid cell. In the wild type cells in presence of O2, the pH of mitochondrial matrix is 8, however in cells along with this mutant S gene, the pH is 7. Explain all these results.

 

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