• Introduction to Coronavirus

-Description of the virus and the group

-Considered emerging pathogens (Martin-Navas& Weiss, 2004).

-SARS infections

• Replication of Coronavirus

-The Virion-description of the virion (Weiss &Navas-Martin, 2005).

-RNA Genome

-Virus proteins

• Coronavirus types and Diseases

-Murine Coronaviruses

-Human Coronaviruses

-Porcine Coronavirus

-Bovine Coronavirus

-Feline Coronavirus

Avian Coronavirus

• The Development and Application of Reverse Genetics Systems

-Full-length CDNA clones

-The MHV genome systems

• The Roles of Coronavirus Proteins in Replication and Pathogenesis

-Spike Proteins

– proteins

-Membrane proteins

-Internal protein

-Small envelope protein

-Group specific proteins

-Replicase proteins (Weiss &Navas-Martin, 2005)

• Mutations of Coronavirus

-Feline Coronaviruses (Licitra et al., 2013).

• The outbreak of severe acute respiratory syndrome (SARS)

-Origins

-Pathogens of SARS

-Outbreaks

-SARS Vaccine development

-Treatment of SARS

-Middle East Respiratory System Coronavirus-MERS-CoV (Coleman &Frieman, 2013).

• Coronavirus Vaccine Development

References

Coleman, M. C.,&Frieman, B. M. (2013).Emergence of the Middle East respiratory syndrome Coronavirus. PLOS Medicine, 9(9) e1003595. Retrieved from http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1003595

Licitra, M.B., Millet, J. K., Reagan, D. M., Hamilton, S. B., Rinaldi, V. D. … Whittake, G. R. (2013). Mutation in spike protein cleavage site and pathogenesis of feline coronavirus.Emerging Infectious Diseases, 19(7).

Martin-Navas, S., & Weiss, R. S. (2004). Coronavirus replication and pathogenesis: Implications for the recent outbreak of severe acute respiratory syndrome (SARS) and the challenge for vaccine development. Journal of Neuro Virology, 10,75-85.

Weiss, R.S.,&Navas-Martin, S. (2005). Carnivorous pathogenesis and the emerging severe acute respiratory syndrome coronavirus.Microbiology and Molecular Biology Reviews, 69(4), 635-664.