Frameshift mutations may or may not be a disaster whenthey occur.

A. What is a frameshift mutation? (First, describe what a”frame” is).

B. Why is the effect of a triple frameshift mutation of the samesign different from that of a single or double frameshift mutationor a triple frameshift mutation of mixed signs?

C. Imagine a gene that codes for a protein of 1000 amino acids.Compare the effect of a triple frameshift minus mutation thatoccurs at +19, +22 and +24 bp and one that occurs at +30, +1500,and +2900 bp.