Some exons in the human genome are quite small (less than 75 bp long). Identification of such “micro-exons” is difficult because these distances are too short to reliably use open reading frame identification of codon bias to determine if small genomic sequences are truly part of an mRNA and a polypeptide. What techniques of “gene-finding” can be used to try to assess if a given region of 75 bp constitutes an exon?