Pharmacology Discussion Questions:

1) Describe the differences between pharmacodynamics and pharmacokinetics.

2) Identify the differences between agonist, antagonist, and partial agonist.

3) Describe the concentration-response relationship.

4) Compare and explain the process of receptor desensitization and supersensitivity.

5) Present the most important processes related to pharmacokinetics.

6) Explain why body fluids pH can affect drug absorption and distribution.

7) Give examples of major drug elimination routes. Explain the process of biotransformation.

8) Present the major factors that affect drug metabolism.

9) Compare hepatic and biliary clearance to renal elimination of drugs.

10) Explain the significance of pharmacogenetics in today’s medicine.

11) Present and compare the mostly applicable routes of drugs administration.

12) Explain the significance of plasma concentration measurement in case of IV injection of drug.

13) Present the definition and significance of clearance calculations.

14) Present the definition and significance of half-time measurement. Give some examples of drugs with short and long half-times.

15) Explain the significance of multiple and prolonged dosing.

16) Explain pharmacokinetic changes with aging.

17) Explain the meaning of first-pass metabolism.

18) Give five examples of drug-disease interactions. Explain why disease can increase the risk of adverse drug reactions.