Mutation results in a loss of protein function

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April 26, 2020
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April 26, 2020

Mutation results in a loss of protein function

You are studying a particular protein, and find that a mutationchanging an alanine amino acid residue within the interior of the protein to a valine resultsin a loss of protein function. You also find that a second mutation (at a differentlocation in the primary structure) changing a leucine residue to a glycine restores thefunction of the mutant protein.

a. Using no more than two carefully constructed sentences, tell mewhy the first mutation results in a loss of protein function?

b. Using no more than two carefully constructed sentences, tell mewhy the second mutation restores protein function?