How genetic disorder affecting a protein

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How genetic disorder affecting a protein

Certain patients have a genetic disorder affecting a protein that provides support to the mitochondria of all the cells in the body. Yet the patients die of heart attacks. One explanation for why the heart, in particular is targeted might be;
a. The loss of mitochondrial function in other tissues reduces the body’s production of energy and therefore puts more strain on the heart
b. The heart relies mainly on mitochondrial metabolism to provide the energy it needs
c. Heart cells may have a much higher concentration of mitochondria than other cells, making the cells more sensitive to dysfunction
d. All of the above e. a and c