Q1. Hereditary non-polyposis colorectal cancer (HNPCC) is an inherited disorder. The genetic defect identified is an error in the mismatch repair mechanism. Which of the following would be an expected result of this mutation?

A) Increased rate of errors by wild-type DNA polymerase

B) Increased rate of formation of pyrimidine dimers

C) increased rate of repair of pyrimidine dimers

D) Decreased ability to repair sure DNA mutations

Q2. Do you think that using recombinant DNA technologies to change the genetic composition of human egg cell is ever justified? If so, what restrictions have to be placed on such a use?