High doses of the caffeine interfere along with the DNA replication checkpoint mechanism within the mammalian cells.  Why then do you assume the Surgeon General has not yet issued a suitable warning to heavy coffee and soda drinkers?  A typical cup of coffee (150 ml) consists of 100 mg of caffeine (196 g/mole). How many cups of the coffee would you have to drink to reach the dose (10mM) needed to interfere along with the DNA replication checkpoint mechanism? (A typical adult contains about 40L of water.)